Chromatin Organisation & Dynamics

The organization of bacterial and archaeal chromatin and its interplay with transcription (Dame)

Bacterial chromosomal DNA is not confined to an envelope-enclosed organelle such as the nucleus in eukaryotes, yet the volume it occupies has to be reduced below that of the cell. An unconstrained chromosomal DNA molecule of 1.6 mm as found in E. coli would form a random coil with a volume of ~200 μm3.

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News & research highlights

NWO awards 1.5 million euro VICI grant to Remus Dame

NWO has awarded a prestigious VICI grant to Remus Dame. With this grant he will strengthen his research programme on dynamic organization of the bacterial genome. Specifically, he will investigate the molecular mechanisms that drive changes in genome organization in response to environmental cues, the effect of these changes on specific environmentally regulated genes and the resulting physiological response.

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Article published

Now online in Nature Reviews Microbiology our review on the interplay between chromatin and transcription in archaea.

E. Peeters, R.P.C. Driessen, F. Werner & R.T. Dame
The interplay between nucleoid organization and transcription in archaeal genomes
Nature Reviews Microbiology. 13(6), 333-341, 2015.


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June 11, 2015: Mini-symposium 'Bacterial genome organization & dynamics'

As kick-off for the HFSP program 'Unfolding the principles of genome folding and dynamics in bacteria' there will be a public mini-symposium with lectures by Remus Dame (LIC), David Grainger (University of Birmingham) and Dieter Heermann (University of Heidelberg).

Leiden University
Leiden Institute of Chemistry
Einsteinweg 55
Room: L144

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