Research

Molecular basis of chromatin function (van Ingen)
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At the heart of the cell, in the nucleus, proteins and nucleic acids come together to maintain and express our genetic information. The interplay of proteins and nucleic acids in both genetic and epigenetic pathways forms the research focus in the Van Ingen group. How do their structures, motions and interactions come together to elicit function? The group’s main research is centered on the molecular basis of chromatin function at the level of its repeating unit, the nucleosome.

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Protein dynamics and interactions (Ubbink)
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Proteins function by forming complexes with other biomolecules. Some of these are tight and well-defined, others are weak and dynamic. We study the biophysical nature of complexes of proteins with other proteins and ligands.

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The organization of bacterial and archaeal chromatin and its interplay with transcription (Dame)
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Bacterial chromosomal DNA is not confined to an envelope-enclosed organelle such as the nucleus in eukaryotes, yet the volume it occupies has to be reduced below that of the cell. An unconstrained chromosomal DNA molecule of 1.6 mm as found in E. coli would form a random coil with a volume of ~200 μm3.

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