A deceptively simple, complicated paper

Sometimes the simple things can be most complicated. You can find our analysis of the NMR signal of three methyl groups now published in the Journal of Magnetic Resonance.

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PNAS publication on protein encounter complexes
Mapping the encounter states

A new approach to characterize encounter states of protein complexes has been published in Proc. Natl. Acad. Sci. USA (PNAS) by the research groups of Prof. Ubbink and Prof. Luchinat (University of Florence).

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ECHO grant awarded
The roles of conserved residues

An NWO ECHO grant has been awarded to Marcellus Ubbink to study protein robustness and the roles of conserved amino acid residues in maintaining the structure and function of enzymes involved in antibiotic resistance. 

Best research paper award

Former visiting PhD-student Fariha Khan recently received the Best Research Paper Award 2013/2014 from the Higher Education Commission (HEC) in Pakistan.

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Review published

Now online in Current Opinion in Structural Biology our review on the various isotope-labelling strategies in the study of macromolecular complexes by NMR.

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NWO awards 1.5 million euro VICI grant to Remus Dame

NWO has awarded a prestigious VICI grant to Remus Dame. With this grant he will strengthen his research programme on dynamic organization of the bacterial genome. Specifically, he will investigate the molecular mechanisms that drive changes in genome organization in response to environmental cues, the effect of these changes on specific environmentally regulated genes and the resulting physiological response.

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Enzyme dynamics studied with paramagnetic NMR
A paramagnetic tag attached to cyt P450cam

Researchers of the Protein Chemistry group published a study that appeared on-line yesterday (June 30) in PNAS on the dynamics of an important redox enzyme.

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Former Protchem PhD student Yoshitaka Hiruma in Science

Yoshitaka Hiruma, who received a PhD from UL in 2014 after doing his research in the Protein Chemistry group, now works as a post-doc for Geert Kops (UMC) and Anastassis Perrakis (NKI) and is first author on a study on spindle check-point signalling published in Science today. Protchem contributed by collaborating on the NMR experiments reported in this article. 

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Article published

Now online in Nature Reviews Microbiology our review on the interplay between chromatin and transcription in archaea.

E. Peeters, R.P.C. Driessen, F. Werner & R.T. Dame
The interplay between nucleoid organization and transcription in archaeal genomes
Nature Reviews Microbiology. 13(6), 333-341, 2015.


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June 11, 2015: Mini-symposium 'Bacterial genome organization & dynamics'

As kick-off for the HFSP program 'Unfolding the principles of genome folding and dynamics in bacteria' there will be a public mini-symposium with lectures by Remus Dame (LIC), David Grainger (University of Birmingham) and Dieter Heermann (University of Heidelberg).

Leiden University
Leiden Institute of Chemistry
Einsteinweg 55
Room: L144

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Remus Dame joins Protein Chemistry group

Dr Remus Dame and his coworkers have joined Protein Chemistry, expanding our research in protein - DNA interactions. Dr Dame uses in vitro and in cell techniques to study how proteins influence the physical and functional properties of DNA.

The website will be updated soon to accommodate the new research lines of Dr Dame and Dr van Ingen (see news item December 2, 2014).

KIEM project awarded

NWO has awarded a KIEM project to Prof. Marcellus Ubbink.

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Hugo van Ingen new assistant professor in Protein Chemistry

The Leiden Institute of Chemistry and the section of Protein Chemistry welcome Hugo van Ingen as a staff member. Van Ingen is appointed as tenure-track assistant professor and will set up his new research group focusing on the molecular basis of chromatin function.

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Human Frontier Science Program grant awarded

A program grant has been awarded to the ‘Chromatin organisation & dynamics’ group and three partner groups at the University of Birmingham (Grainger), Caltech (Jensen) and University of Heidelberg (Heermann).

For more information on this program click here 

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Science in Transition

Prof. Frank Miedema, a leading person in the new movement called Science in Transition, will speak in the Gorlaeus Laboratories on March 24, 2014 at 15:30 in lecture theatre C1.

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Article published

Now online in Molecular Microbiology our studies on the motility of Sulfolobus acidocaldarius and its unique swimming organelle, the archaellum. Unexpectedly, our studies reveal that this type IV pilus like structure is capable of rotation and that its rotation drives swimming motility.

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Article published

Now online in ChemBioChem our studies on the effect of the HU protein on DNA helix stability and the implications for its action as a potential roadblock for DNA based motor enzymes.

R.T. Dame, M.A. Hall & M.D. Wang
­Single-molecule Unzipping Force Analysis of HU-DNA complexes
ChemBioChem, 2013

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Upcoming conference: The Biology and Physics of Bacterial Chromosomes - June 16-18, 2014 - Birmingham, UK

The second international workshop on 'The Biology and Physics of Bacterial Chromsomes'  will be organized at the Univeristy of Birmingham, United Kingdom. The workshop is organized by David Grainger, Olivier Espeli, Paul Wiggins and Remus Dame.

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Upcoming conference: Joint Dutch Chromatin Meeting & NVBMB Fall Symposium - October 29, 2013 - Erasmus MC, Rotterdam

The 'Joint Dutch Chromatin Meeting & NVBMB Fall Symposium'  will be organized at the Erasmus MC, Rotterdam. The meeting is organized by Adriaan Houtsmuller, Wim Vermeulen, Joost Gribnau, Ben Tilly and Remus Dame.

Confirmed invited speakers:

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ECHO grant for Marcellus Ubbink

An ECHO grant has been awarded to Marcellus Ubbink for research in dynamic protein complexes. The project is aimed at manipulating a protein interface to change the encounter state of the complex. This state is the essential prelude to forming an active protein-protein complex. The project will elucidate how important electrostatic interactions are for homing in on the final binding site.