Welcome to Macromolecular Biochemistry
Protein Chemistry April 2015

Macromolecular Biochemistry (formerly Protein Chemistry) is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Marcellus Ubbink.

The research is aimed at understanding protein & nucleic acid structure, function and interactions. Particular interests comprise protein-protein interactions & enzyme function (Prof. Ubbink) and chromatin research, such as structure and function of nucleosomes (Dr. van Ingen) and biophysical aspects of protein - DNA interactions (Dr. Dame).

The section houses equipment for recombinant protein production and a variety biophysical characterisation methods.


Enzyme dynamics studied with paramagnetic NMR
A paramagnetic tag attached to cyt P450cam

Researchers of the Protein Chemistry group published a study that appeared on-line yesterday (June 30) in PNAS on the dynamics of an important redox enzyme.

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Former Protchem PhD student Yoshitaka Hiruma in Science

Yoshitaka Hiruma, who received a PhD from UL in 2014 after doing his research in the Protein Chemistry group, now works as a post-doc for Geert Kops (UMC) and Anastassis Perrakis (NKI) and is first author on a study on spindle check-point signalling published in Science today. Protchem contributed by collaborating on the NMR experiments reported in this article. 

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Article published

Now online in Nature Reviews Microbiology our review on the interplay between chromatin and transcription in archaea.

E. Peeters, R.P.C. Driessen, F. Werner & R.T. Dame
The interplay between nucleoid organization and transcription in archaeal genomes
Nature Reviews Microbiology. 13(6), 333-341, 2015.


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June 11, 2015: Mini-symposium 'Bacterial genome organization & dynamics'

As kick-off for the HFSP program 'Unfolding the principles of genome folding and dynamics in bacteria' there will be a public mini-symposium with lectures by Remus Dame (LIC), David Grainger (University of Birmingham) and Dieter Heermann (University of Heidelberg).

Leiden University
Leiden Institute of Chemistry
Einsteinweg 55
Room: L144

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