Welcome to Macromolecular Biochemistry
MacBio April 2016

Macromolecular Biochemistry (formerly Protein Chemistry) is a section of the Leiden Institute of Chemistry at Leiden University, comprizing the PIs Marcellus Ubbink, Remus Dame, and Hugo van Ingen.

The research is aimed at understanding protein & nucleic acid structure, function and interactions. Particular interests comprise protein-protein interactions & enzyme function (Prof. Ubbink) and chromatin research, such as structure and function of nucleosomes (Dr. van Ingen) and biophysical aspects of protein - DNA interactions (Dr. Dame).

The section houses equipment for recombinant protein production and a variety biophysical characterisation methods.


ECHO grant awarded
The roles of conserved residues

An NWO ECHO grant has been awarded to Marcellus Ubbink to study protein robustness and the roles of conserved amino acid residues in maintaining the structure and function of enzymes involved in antibiotic resistance. 

Best research paper award

Former visiting PhD-student Fariha Khan recently received the Best Research Paper Award 2013/2014 from the Higher Education Commission (HEC) in Pakistan.

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Review published

Now online in Current Opinion in Structural Biology our review on the various isotope-labelling strategies in the study of macromolecular complexes by NMR.

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NWO awards 1.5 million euro VICI grant to Remus Dame

NWO has awarded a prestigious VICI grant to Remus Dame. With this grant he will strengthen his research programme on dynamic organization of the bacterial genome. Specifically, he will investigate the molecular mechanisms that drive changes in genome organization in response to environmental cues, the effect of these changes on specific environmentally regulated genes and the resulting physiological response.

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